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Skipping dose levels (e.g., jumping from 0.6 mg to 1.8 mg) should be avoided, as this significantly increases the risk of adverse events

Gut, 67(7), 1201-1212

Advanced protocol Experienced researchers sometimes use higher doses, though diminishing returns and increased side effect risk apply

Doping with aromatase inhibitors and oestrogen receptor modulators in steroid users: analysis of a forum to identify dosages, durations and adverse drug reactions

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The researchers proposed that the compounds effects on muscle function operate through boosting NAD+ levels by inhibiting NNMTs consumption of nicotinamide, more substrate is available for NAD+ synthesis via the salvage pathway, supporting mitochondrial function and energy metabolism in aged skeletal muscle