The thiamine-induced increases in contractions of the intestine smooth muscle and peristalsis, observed in a number of independent in vitro experiments on muscle strips of gastrointestinal tract (207, 219222), support the action of thiamine on ACh signaling in ENS in the absence of central regulation (236)
We can dispense up to 12 weeks of medication at a time
However, its poor permeability and foul odor limit its use in skin applications
The next critical step in this research involves conducting in vivo studies to confirm neuroprotective activity, for example, using established mouse models
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