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During the procedure you may experience sensations of pulling, tugging, mild pinching, intense cold, tingling, stinging, aching, cramping and discomfort at the treatment site

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Injection volumes stay small (0.05-0.1 mL), which community sources describe as more comfortable for subcutaneous delivery

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No specific contraindications for combination therapies have been established, but prudent clinical practice suggests monitoring for unexpected interactions when initiating novel combination regimens