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Furthermore, GSTP1-1 has also been shown to bind and inhibit tumor necrosis factor receptor-associated factor 2 (TRAF2), an upstream activator of JNK, thus blocking the MAPK/JNK signaling cascade at multiple levels 29
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Following these early observations, the up-regulation of plant GST genes has often been used as an indicator of oxidative stress and HR in plant-bacterium interactions (Alvarez et al., 1998
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Table prepared from various references
These patterns are clinically dynamic: Both global and locus-specific methylation signals associate with disability scores and can be modified by disease-modifying therapies, highlighting the plasticity of the MS methylome (138,139)
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