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For gastric protection or ulcer repair , oral administration may offer localized benefits, but should be approached cautiously due to variability in absorption

Troeman DP, Postma DF, van Werkhoven CH, Oosterheert JJ

Melanoma cells arising from the immature melanocytes that have become arrested in the lamina propria of the oral mucosa proliferate, forming nodular aggregates in the lamina propria/submucosa with or without breaching the subepithelial basement membrane

Moreover, metformin can directly protect endothelial cells from injury, which is beyond its glucose-lowering effects 7,8