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QSAR modeling using large-scale databases: Case Study for HIV-1 reverse transcriptase inhibitors

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Specifically, HC induced a significant change in 15 proteins (i.e., 9 and 6 up- and down-regulated, respectively) involved in autophagy, including the down-regulation of NPC1 (Nieman-Pick type C) and QSOX1 (quiescin sulfhydryl oxidase 1) and the up-regulation of HMOX1 (heme oxygenase 1) and KDM4A (lysine demethylase 4A)

Despite the relative stable abundance of glutathione in infested susceptible plants, there were, however, significant changes in metabolic pathways of glutathione in these plants

Gene expression studies (Pickart and Margolina, 2018) identified that GHK-Cu reverses the gene expression signature of COPD, metastatic colon cancer, and aggressive prostate cancer cell lines toward a healthier profile, suggesting systemic regenerative potential beyond cosmetic applications