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Semaglutide is not a direct cholesterol-lowering medication

Executive summary RGA has quantified the expected mortality and morbidity impacts of incretin-based drugs, including GLP-1s, approved as anti-obesity medications (AOMs) and diabetes treatments in the US, UK, Canada, and Hong Kong

References Garcia, E

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Those who had a prescription had a 40% lower rate of overdose than those without a prescription, the study found

The total heart rate increase seen with retatrutide (~57 bpm) therefore reflects the combined contribution of both GLP-1 and glucagon receptor activation on cardiac tissue a pharmacological signature unique to this drug class