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The absence of exendin-4 effect in obese rats maintains AMPK activity at a level of activation similar to the lean animals after the administration of exendin-4 [83] (Figure 5)

50 nM), negative isotype control (ISO), and PMA-ionomycin (PMA-I) positive control ( n = 9)

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As described already, glucotoxicity, endothelial damage by inflammation, oxidative stress and cytokine production contribute to an increased risk of thromboembolic complications and of damage to vital organs in patients with diabetes mellitus 60 (Fig