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Finally, we present the horizons and challenges in the field for future development

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[DOI] [PubMed] [Google Scholar] 52.Zhao Z., Li R., Wang X., Li J., Yuan M., Liu E., Liu T., Li G

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Therefore, melasma treatment, especially in patients with dark skin types classified as Fitzpatrick types IV to VI, is challenging due to the possibility of relapse and also susceptibility to post-inflammatory hyperpigmentation (PIH) (Rodrigues and Pandya, 2015)

In Parkinsons disease, gut dysbacteriosis and gastrointestinal dysfunctions can precede the neurological symptoms, suggesting a pathophysiological role of the intestine