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pioneered the discovery of histone lysine lactylation (Kla) in mammalian cells using tandem mass spectrometry and isotopic tracing (4)

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However, the insufficient stability of acid-cleavable linkers severely limits their application in ADCs, and a phenylketone-derived hydrazone linker was hydrolyzed with a t 1/2 = 2 days in human and mouse plasma

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[DOI] [PMC free article] [PubMed] [Google Scholar] 25.Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, Frosch MP

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