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The effect of this synergistic treatment is ASS-dependent, and the activity of the enzymes mentioned above can be restored by transfection of ASS, eliminating the sensitivity of tumor cells to ADI-PEG20 combined with 5-FU treatment

Zhang SJ, Li YF, Wang GE, Tan RR, Tsoi B, Mao GW et al (2015) Caffeine ameliorates high energy diet-induced hepatic steatosis: sirtuin 3 acts as a bridge in the lipid metabolism pathway

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Both medications can cause side effects, especially when starting treatment or increasing the dose

They are powerful metabolic medicines with visible dermatological consequences and early anti-inflammatory promise

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