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However, two recent meta-analyses have revealed the high incidence of AP related to DM observing that approximately 18%-23% patients of AP will develop DM within three years of discharge[6,16]

Moreover, age also influences the loss of GSH, even in healthy individuals, yet antioxidant defenses decrease [133]

Another factor to consider is gastrointestinal tolerance

Weeks 1-4 typically show no visible changes

These typically resolve within hours to days and can be minimized through proper technique and site rotation

By far, the most common side effects are gastrointestinal, specifically nausea, vomiting, diarrhea, and constipation