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The microbial translocation through the disrupted tight junctions of GI cells promotes systemic inflammation and can alter the BBB or cause other direct CNS effects via the Vagus nerve

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In post-mortem specimens from AD victims, reactive, hypertrophic astrocytes as well as reactive microglia surround senile plaques, thus creating a protective barrier

Epub 2008 Aug 30

Vitamin D supplementation for the prevention of depression and poor physical function in older persons: the D-Vitaal study, a randomized clinical trial

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