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Patients taking diabetes medications or blood pressure medications should be especially careful because weight loss and appetite changes may alter medication needs

But then we realized it was so good & had so many benefits for people that weren't fasting it wouldn't be right just to keep it to ourselves

Early weight changes begin

This chart shows clinical trial protocols from published studies

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Because of this mechanism, Rybelsus must be taken: On an empty stomach With a small amount of water At least 30 minutes before food, beverages, or other medications Orforglipron does not appear to require the same strict timing rules