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Klotho, a transmembrane protein that is classically known for its co-receptor activity with fibroblast growth hormone receptors, has recently been characterized as a possible secretagogue for GH

Despite doctors constantly reminding us that the key to weight loss is calories consumed versus calories burned, drug manufacturers continue to try to find ways to get around this tried-and-true method of diet and exercise

They're both approved to treat type 2 diabetes, and each have twin medicines approved for weight loss

The medication helps by curbing appetite and slowing digestion, which decreases overall calorie intake and supports steady weight loss

Clinical Trial Results Researchers Watch Earlier phase 2 work found that once-weekly cagrilintide produced significant body-weight reductions in people with overweight or obesity and supported continued development of amylin-pathway medications

doi: 10.1016/j.actbio.2023.10.024 41 LuoYLiCZhangYLiuPChenHZhaoZet al