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Now here is the nuance that most articles miss

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Archives of Internal Medicine, 169(4):335-41

In its milder forms, anhedonia can look like a sudden disinterest in hobbies, a flat emotional response to good news, or a strange inability to feel excited about things you used to anticipate eagerly

Furthermore, previous clinical studies have often suffered from small sample sizes or limited medical databases, thereby restricting their broader generalizability and use as proxies for performance estimates in routine clinical practice

54,57 Beyond the pancreas, GLP-1 receptors are widely expressed in extrapancreatic tissues, including the heart, vascular smooth muscle, lungs, liver, gastrointestinal tract, vagus nerve, and enteric nervous system