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is supported by the National Key R&D Program of China (2022YFA1303000), the National Natural Science Foundation of China (32225025, 32321004, 92254305), the CAS Project for Young Scientists in Basic Research (YSBR-076) and the New Cornerstone Science Foundation through the XPLORER PRIZE

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3.2.4 Developmental and drug-induced microbiome disruption Disruptions to the gut microbiome during early development or the initial phases of psychiatric illness may influence the trajectory of mental disorders (Lavebratt et al., 2019) reported that early-life antibiotic exposure is linked to modestly increased risks for several childhood psychiatric disorders, including mood disorders, suggesting sensitive developmental windows for microbiome perturbations (Lavebratt et al., 2019)