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The medication is structurally modified to resist degradation by the enzyme dipeptidyl peptidase-4 (DPP-4) and includes an albumin-binding side chain, which extends its duration of action compared to native GLP-1

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Building Blocks: Peptide Therapeutics: References: Li, W., Zhou, Q., Cong, Z

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Dosing is typically initiated at a low level and gradually titrated upward to minimize gastrointestinal side effects and improve tolerability