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Without adequate glutathione to support detoxification, these toxic Phase I intermediates would accumulate, causing massive oxidative stress, mitochondrial dysfunction, and ultimately, severe liver damage

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According to the World Health Organization (WHO), Many skinlightening products work by reducing melanin levels but often contain hazardous substances such as mercury, which WHO classifies as one of the ten chemicals of major public health concern

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De FilippoCCavalieriDDi PaolaMRamazzottiMPoulletJBMassartSet al

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Pharmacological treatment typically begins with non-insulin antihyperglycemic agents, either as monotherapy or in combination

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These multi-omics findings were further translated to human disease when Wfdc2 was validated as a potential biomarker in DKD patient samples (Shi et al., 2023a)

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