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This could trigger a positive feedback cycle whereby protein aggregates trigger the aggregation of other proteins in a chain reaction that eventually captures elements of the proteostatic mechanisms in place to counteract them

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Vitamin D regulates calcium uptake and supports the collagen matrix in bones, helping maintain their strength and reducing the risk of fractures

6.4 Management of autoimmune diseases Autoimmune illnesses that include rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis have long been thought to be T helper cells (Th cells) 1-dominant

10.1111/j.1572-0241.1999.00797.x 156