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Statements Author contributions VS conceptualized, analyzed, and wrote the draft

Normally, fibroblast activity declines dramatically with age

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We initially performed scratch and migration assays on LPS-stimulated BV2 cells to evaluate their proliferation and migration abilities after microglia phenotype transition to investigate the effect of microglia polarization toward M2 phenotype on A clearance

Red flag symptoms requiring immediate evaluation include unintentional weight loss over 10 pounds, persistent vomiting, black or bloody stools, or difficulty swallowingthese may indicate ulcers, inflammatory bowel disease, or malignancy

SGLT2 inhibitors might not cause EDKA by themselves but instead create a predisposition that can lead to the condition when certain triggering factors are present