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We found that NRF2 promotes the activity of the serine biosynthesis pathway, which is required for the in vitro and in vivo growth of lung cancer cells with high NRF2 activity (DeNicola et al., Nat Genet 2015)

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These adverse effects can be uncomfortable and may deter individuals from continuing supplementation

[10] These trials were not specifically designed to assess cancer outcomes, but they provide valuable safety data from well-controlled studies

Crit Rev Toxicol 1999;29(3):283-330