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Participants who received semaglutide injections lost significantly more weight than those on the placebo, with an average weight loss of around 15% of their initial body weight over the study period

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The GLORY-1 trial used 4 mg and 6 mg maintenance doses

However, reduced appetite can make it harder to notice appetite changes caused by thyroid hormone imbalance, so maintaining open communication with your doctor about any unusual symptoms is especially important

Gut dysbiosis may thus result in deficiencies of critical micronutrients, notably iodine, selenium, iron, zinc, and vitamin D, which are indispensable for optimal thyroid function and regulation (Knezevic et al., 2020)