Wegovy is generally recommended for adults who are considered overweight or obese and have struggled to lose weight through diet and exercise alone
Escalation of LT4 monotherapy is generally discouraged due to an unfavourable riskbenefit profile
N Engl J Med 380:347357 Cannon CP, Pratley R, Dagogo-Jack S, Mancuso J, Huyck S, Masiukiewicz U, Charbonnel B, Frederich R, Gallo S, Cosentino F, Shih WJ, Gantz I, Terra SG, Cherney DZI, McGuire DK (2020) VERTIS CV Investigators
The doses used were standard doses
doi:10.1016/S0140-6736(05)61032-X Lu X, Xie Q, Pan X, et al
Although there are a variety of LRRK2 knockin mice and transgenic mice based on the above mutations, the existing LRRK2 knockin mice do not develop PD-related behavioral and pathological changes 4,5