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The FDA issued a Drug Safety Communication in 2024 stating that their review did not find clear evidence of an increased risk of suicidal thoughts or actions with GLP-1 receptor agonists, though they continue to evaluate this safety concern

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However, despite sharing the same active ingredient, semaglutide, the two arent the same product per dosing, potency, and titration schedules

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Diabetes guidelines from major organizations support adding SGLT-2 inhibitors and/or GLP-1 agonists to metformin therapy for patients with type 2 diabetes and established CVD, 510 and most guidelines support their use in patients at high risk of cardiovascular events