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Protein arginine methyltransferase 1 ablation in motor neurons causes mitochondrial dysfunction leading to age-related motor neuron degeneration with muscle loss

After performing automatic shimming using the Fast Automatic Shim Technique with Echo-planar Signal readout for Mapping Along Projections (FASTEST MAP, Siemens prototype sequence), manual shimming was performed to make the linewidth of the water spectrum smaller than 20 Hz

The identified mechanisms include: Competitive Reuptake Inhibition: Amphetamine enters the presynaptic neuron either by passive diffusion or by acting as a competitive substrate for the plasma membrane monoamine transporters

Monitoring Strategies Appropriate monitoring involves both laboratory assessment and clinical evaluation

Front Drug Discov (Lausanne)