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The medication is doing its job by giving you back normal hunger cues instead of that constant food noise

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In the phase 2 obesity trial, these heart-rate changes were reported as peaking during the study and then declining later

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DAMPs also impact Kupffer cells, activating the nucleotide-binding oligomerization domain-like receptor (NLR) Family, Pyrin Domain-Containing 3 protein (NLRP3), a type of inflammasome leading to IL-1 secretion and inflammation, and pyroptosis, releasing more DAMPs and perpetuating a destructive cycle (Peiseler et al., 2022)

It helps regulate blood sugar, slows stomach emptying and contributes to feelings of fullness