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Advances in Experimental Medical Biology 1118:29-61

Canagliflozin (Invokana) Dapagliflozin (Farxiga) Empagliflozin (Jardiance) Ertugliflozin (Steglatro) These medications are effective in lowering the A1c, which helps to protect heart and kidney function

During this process, reactive radicals are produced as byproducts

Also, prolonged NSW ( 10 years) correlated with hypomethylation in NR1D1, and hypermethylation of CSNK1E, a kinase regulating PER proteins downstream of CLOCK 215

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