Typically, the skin-lightening effects last for a few months, and maintenance treatments are often needed to preserve the results over the long term.
The thymosin beta-4 fragment literature is less well-characterized on pharmacokinetic parameters than the full protein, and that gap is worth noting in any methods section that cites it
[DOI] [PubMed] [Google Scholar] 97.Mikkelsen K., Stojanovska L., Tangalakis K., Bosevski M., Apostolopoulos V
doi: 10.3389/fcell.2021.650748
It upregulates the expression of early growth response protein 1 (EGR-1), a transcription factor that controls over 30 downstream genes involved in cytokine production, growth factor signaling, and extracellular matrix remodeling
Results vary based on your starting levels and lifestyle