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First you will see a report from 1971 that in a study on excessive prescribing, B12 treatment was singled out, possibly due to the idea that GPs were giving patients B12 injections, willy nilly as a tonic

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Since this 2012 publication, there has been very little new research into this question

Clinicians are still responsible for making decisions appropriate for each patient

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Methods 103:120127 Biesiada M, Pachulska-Wieczorek K, Adamiak RW, Purzycka KJ (2016) RNAComposer and RNA 3D structure prediction for nanotechnology