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In Type 2 diabetes, this problem gets worse

DPP-4 inhibitor plus SGLT-2 inhibitor as combination therapy for type 2 diabetes: from rationale to clinical aspects

Influencing factors : Age : Older individuals have less collagen and elastin, making their skin less likely to retract

Commercial plans vary significantly: some require BMI above 30, documented failed diet-and-exercise attempts lasting 6 months, or comorbidities like hypertension

Its more effective than diet and exercise alone for severely obese patients

And basically that paradigm says that, and the reason its called a paradigm is because its counterintuitive