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A 2018 meta-analysis of 17 randomized controlled trials found that ALA supplementation significantly reduced total cholesterol, LDL-C, and triglycerides, though it had no consistent effect on HDL-C

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doi: 10.3892/etm.2016.3742 86 PatzeltCSchugG

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15,16 Therefore, a balance exists in how folate is distributed between these two metabolic pathways, with competition for the 5,10-methyleneTHF cofactor existing at the nexus of these pathways