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doi: 10.1080/00032710802568655 54 Trujillo-CceresSJTorres-SnchezLBurguete-GarcaAIOrbe OrihuelaYCVzquez-SalasRAlvarez-TopeteEet al

What is B12, exactly

The notion that oxidative damage likely influences konzo susceptibility has been long theorized since this disease is associated with the consumption of cyanogenic compounds that are well known to increase radicals either through direct inhibition of mitochondrial respiration or through toxicity of the downstream metabolites of cyanide 12,18

Histone modifications, particularly histone deacetylase (HDAC) activity, play a key role in both diseases, with HDAC inhibitors like valproic acid showing therapeutic potential in lowering blood pressure and inhibiting lung cancer cell proliferation