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Am J Surg 180(1):3336 Drucker DJ (2024) Efficacy and safety of GLP-1 medicines for type 2 diabetes and obesity

All patients initiated injectable semaglutide or tirzepatide for obesity or type 2 diabetes and stopped the medication within three to 12 months

What fewer people understand is just how dramatically the use of these medications has changed in a very short period of time, and what that surge means for patients trying to access them

New mechanisms for weight loss are continually being explored, offering new potential drug targets from cannabinoid receptor blockers, nucleotide-binding domain, leucine-richcontaining family, pyrin domaincontaining-3 (NLRP3) inhibitors, free fatty acid receptor 2 (FFA2) inhibitors and gene-editing RNA therapy

In this way, indulgent-smelling products might offer a non-caloric form of comfort or reward

Why starting low matters The escalation protocol is not arbitrary