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Administration of Wuzhi tablet 3 days prior to APAP treatment could significantly alleviate hepatoxicity in a dose-dependent manner along with reduction in the activation of JNK (Fan et al., 2014)

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Iron deficiency also disrupts Ca 2+ homeostasis: non-selective cation channels in the RBC membranecritical for Ca 2+ entryare upregulated by iron depletion, possibly via ROS-mediated gating