PCOS is a hormonal and metabolic disorder that occurs in women of reproductive age and is associated with high androgen levels and insulin resistance
Drug facts are checked against the approved prescribing information and the published registration trials
They were originally developed for management of type 2 diabetes, but have since become a common treatment for weight management within the UK
However, because they stimulate the body's natural growth hormone (GH) productionleading to increased IGF-1 levels, muscle synthesis, and fat lipolysisthey are heavily associated with peptides used in bodybuilding and are frequently grouped with peptides researched for weight loss
A recent study found that patients on GLP-1 agonists can expect an average loss of 7% of midfacial volume, primarily in superficial fat pads, for every 10 kg (approximately 22 pounds) of weight lost
In the JAMA paper: expression of the GLP-1 receptor in the human optic nerve and GLP-1 RAinduced enhanced sympathetic nervous system activity might influence optic nerve head perfusion. =Rapid lowering of blood glucose (and rapid change in metabolic state) in persons with pre-existing retinopathy may worsen ocular microvascular conditions (though this is more established with insulin rather than semaglutide specifically)
