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The experimental data from rats suggest that the inhibitory effect of GLP-1 on gastric motor function is mediated by the afferent vagal nerve, through interaction with GLP-1Rs located in vagal afferent fibers that transmit sensory signals to the brain (161)

Seino Y, Terauchi Y, Osonoi T, Yabe D, Abe N, Nishida T, et al

Work with specialists who focus on semaglutide treatments and medical weight loss

While semaglutide activates only the GLP-1 receptor, tirzepatide targets both GLP-1 and GIP receptors, creating a synergistic effect that clinical trials show produces greater weight reduction in many patients

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