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Revisiting the complexity of GLP-1 action from sites of synthesis to receptor activation

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The FDA's pharmacovigilance system continues monitoring adverse event reports for all GLP-1 medications, and no formal warning has been issued specifically linking semaglutide or tirzepatide to appendicitis as a class effect

Lugnier, C

In addition, an emerging oral drug called DPP-4 inhibitors is also widely used in clinics

On the one hand, they regulate some of the most conserved and powerful physiological processes in humans, including stress adaptation, reproduction, inflammation, autonomic control, and tissue repair