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To do so, Se-species have to cross the bloodbrain barrier (BBB) and/or bloodcerebrospinal fluid barrier (BCB) of the choroid plexus

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Therapeutic strategies that directly reduce mortality and extend healthspan are therefore urgently needed

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Endocrinology 149:23412351 Lien F, Berthier A, Bouchaert E et al (2014) Metformin interferes with bile acid homeostasis through AMPKFXR crosstalk