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Both 25-hydroxylases (CYP2R1 and CYP27A1) were expressed in the liver, while CYP27A1 expression was seen only in cultured hepatocytes (FL83B mouse hepatocyte cell line)

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Among these, computational trajectory analysis has become a widely adopted method for reconstructing the dynamic evolution of various kidney cell types, including stromal fibroblasts, epithelial cells, and immune populations, throughout the progression of diabetic injury (Tan et al., 2024)

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Silymarin and silybin, its major active component, have also been noted to reduce bile cholesterol content in both rats and human subjects (Nassuato 1983