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Abbas et al., 2023a) and exhaustion of antioxidant defenses, like downregulation of GSH and the Nrf2/heme oxygenase-1 signaling (Bu et al., 2018)

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The selectivity arises because senescent cells are uniquely dependent on FOXO4-mediated p53 sequestration for survival, while non-senescent cells employ multiple redundant anti-apoptotic mechanisms

10.1016/j.cpcardiol.2022.10152536455798 129 Drivelegka P, Forsblad-dElia H, Angers O, et al