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In addition, the absence of FDA approval also means that manufacturers are not required to provide evidence regarding efficacy of their products

Materials and methods Animal experiment Female homozygous leptin receptor-deficient (db/db) mice on a C57BL/6 background ( n = 40) and wild-type (WT) C57BL/6 mice ( n = 20), purchased from the Animal Laboratory Center of Nanjing University (China), were used in this study