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Most of the total weight loss happens in the first 6 to 9 months
The activation of the glyoxalase system is precisely synchronised with the ascorbateglutathione (AsA-GSH) cycle, which includes APX, GR, MDHAR, and DHAR, to maintain redox homeostasis and mitigate oxidative damage
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This concern relates to a common physiological principle known as down-regulation , where the body reduces its sensitivity to a hormone when it receives a strong external signal for an extended period
