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Trial REDEFINE 2 Phase 3 Duration 68 weeks Population (N) 1,206 adults with T2D + obesity/overweight Key Result 13.7% mean weight change vs 3.4% placebo (treatment-policy)

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Metabolite concentrations were determined using DSS as a reference compound and reported in M

have shown that mechanical load in vivo promotes the production of O 2 in mitochondria of chondrocytes, and the expression of SOD1 and SOD2 in mitochondria decreases, while mitochondrial dysfunction induced by superoxide in mitochondria will further lead to cartilage degeneration (Koike et al., 2015)

The funders had no role in the design, implementation, analysis or writing up of the manuscript

Ozempic is a brand-name injectable medication originally developed for type 2 diabetes management