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Current evidence for a role of GLP-1 in Roux-en-Y gastric bypass-induced remission of type 2 diabetes

GLP-1 analogs are used in diabetic patients with metformin contraindication, and hemoglobin A1C (hbA1c) levels greater than 1.5% over target, or those who are unable to gain desired hbA1c level in three months, mainly in patients with atherosclerosis, congenital heart disease, or chronic renal disease

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Some individuals also experience modest improvements in their blood sugar levels, especially if using semaglutide for diabetes management

Intriguingly, Pcsk9 mRNA trended higher in Dpp4 / mice and was increased in Dpp4 Gut/ mice, whereas Pcsk9 / mice exhibited reduced postprandial TG, attributed to reduced lymphatic chylomicron secretion and enhanced hepatic clearance (33)

But before you evaluate any product in this space - supplement or pharmaceutical - you should actually understand what GLP-1 does in your body