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However, a recent clinical study reported that the infusion of exendin 9-39, a GLP-1R antagonist, did not affect ad libitum food intake in post-RYGB patients, although the authors also reported a concomitant increase in plasma levels of the anorexigenic hormone PYY (discussed below), which might offset the orexigenic effect of GLP-1R antagonism (94)

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