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They found 35 studies that were all done on laboratory animals 35
Schimel, A
upon observing 5 cases of longitudinal pachymelanonychia, in which the histological findings were of acanthoma of the nail matrix producing onychocytes.49 All cases described thus far have occurred on the fingers, as a single lesion, characterized by localized thickening of the nail plate (pachyonychia), longitudinally brownish melanonychia (variable pigmentation from mild to intense), and subungual keratosis at the free edge.38,4952 Only one case was described as a hypopigmented variant, in which xanthonychia was observed instead of melanonychia.53 A well-defined longitudinal melanonychia and subungual keratosis at the free edge/hyponychium are better visualized with dermoscopy (Fig
Under oxidizing conditions, copper ions inhibit cytosolic mitoTAD and MAD key enzymes Cdc48, while the expression of matrix protease CLpP is related to ATP7A levels [157, 158]
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