First, although semaglutide's efficacy estimates were derived from the robust STEP 8 trial, long-term extrapolation of weight trajectories and complication risks required assumptions and the application of published risk equations
Baseline body weight in STEP 1, STEP 3, and STEP 8 was approximately 105 kg, and slightly lower (approximately 100 kg) in STEP 2, which focused on patients with type 2 diabetes and even lower in STEP 4 (approximately 96 kg), which featured a 20-week run-in where all patients received semaglutide before randomization
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