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Three decades ago, Saugstad posited these conditions to be various facets of a single entity, the oxygen radical disease in neonatology, which highlighted the reactive oxygen species (ROS)-surge after asphyxia-oxygenation sequence

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Notably, under specific conditions, palmitoylation is sufficient to partially relieve the autoinhibition mediated by the C-terminal domain, enabling full-length, uncleaved GSDMD to form functional plasma membrane pores [110]

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Lin et al.5 reported ring-like pattern and its variant (fish scale-like pattern and hyphal pattern) in 20 labial and 4 penile lesions of mucosal melanotic macules