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And in blood vessels that are already less flexible or have cholesterol plaques, reintroducing estrogen in the form of hormone replacement therapy can increase the force and speed of blood flow with each heartbeat, sometimes causing a plaque in a vessel to break off and raising the risk of serious problems like heart attack, stroke, or blood clots, says Chervenak

It comes in a single-use self-injectable pen that you take once per week

Medical history review identifies potential contraindications

Clinical experience and patient reports have identified several evidence-based strategies that significantly reduce GLP-1-related nausea

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Microdose semaglutide may also be useful for patients who want to test tolerability before moving into a standard-dose pathway